منابع مشابه
Speciation Dynamics: Generating Selective Pressure Towards Diversity
Recent approaches in evolutionary robotics (ER) propose to generate behavioral diversity in order to evolve desired behaviors more easily. These approaches require the definition of a behavioral distance which often includes task-specific features and hence a priori knowledge. Alternative methods, that do not explicitly force selective pressure towards diversity (SPTD) but still generate it, ar...
متن کاملMetabolic model for diversity-generating biosynthesis.
A conventional metabolic pathway leads to a specific product. In stark contrast, there are diversity-generating metabolic pathways that naturally produce different chemicals, sometimes of great diversity. We demonstrate that for one such pathway, tru, each ensuing metabolic step is slower, in parallel with the increasing potential chemical divergence generated as the pathway proceeds. Intermedi...
متن کاملImmunoglobulin Genes: Generating Diversity with AID and UNG
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
متن کاملGenerating neuronal diversity in the retina: one for nearly all.
Visual perception of our environment essentially depends on the correct assembly of seven principal cell types into the functional architecture of the neuroretina. During retinogenesis these cell types derive from a common population of multipotent retinal progenitor cells (RPCs) residing in the inner layer of the optic cup. In contrast to other well studied regions of the developing CNS, retin...
متن کاملSelective Ligand Recognition by a Diversity-Generating Retroelement Variable Protein
Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how recognition is achieved by DGR variable proteins. Here, we present the structure of the Bordetella bacteriophage DGR variable protein major tropism determinant (Mtd) bound to the receptor pertactin, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1996
ISSN: 0028-0836,1476-4687
DOI: 10.1038/379130a0